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A Composite Study of Coagulation Milieu in Covid-19: Experience from a Tertiary Care Centre from India

Gopal K Bohra1, Abhishek Purohit1, Deepak Kumar1

  • 1Department of Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Cardiovascular & Hematological Disorders Drug Targets
|December 2, 2021
PubMed

Insights

COVID-19 severity is linked to coagulation and inflammation. Key indicators like D-dimer and hs-CRP predict mortality, highlighting their role in disease progression and patient outcomes.

Area of Science:

  • Medical Research
  • Pathophysiology
  • Clinical Diagnostics

Background:

  • Understanding COVID-19 pathogenesis requires investigating the interplay between coagulation and inflammation.
  • Previous studies suggest a complex relationship between these mediators and disease development.

Purpose of the Study:

  • To analyze coagulation parameters and inflammatory markers in COVID-19 patients.
  • To correlate these markers with disease severity and patient outcomes.

Main Methods:

  • A single-center observational cross-sectional study involving 230 COVID-19 patients.
  • Measurement of procoagulants (PT, APTT, D-dimer, LA, fibrinogen, F-VIII), anticoagulants (PC, PS, antithrombin), and inflammatory markers (IL-6, hs-CRP).

Main Results:

  • Disease severity correlated with increased procoagulant and inflammatory markers (PT, APTT, D-dimer, fibrinogen, F-VIII, IL-6, hs-CRP).
  • Anticoagulant levels (PC, Antithrombin) decreased with increasing disease severity.
  • Advanced age, high D-dimer, and high hs-CRP were independent predictors of mortality.

Conclusions:

  • Elevated coagulation and inflammatory markers are associated with COVID-19 severity.
  • Specific markers (Age, D-dimer, IL-6, hs-CRP, APTT, fibrinogen, Factor VIII) are significantly higher in moderate to severe cases.
  • Advanced age, high D-dimer, and high hs-CRP predict poor outcomes in COVID-19 patients.
Abstract

Keywords:
COVID-19anti-coagulation parameterscoagulation parametersinflammatory markerspro-coagulation parameterstertiary care centre.

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