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Determining the Relationship between Triglycerides and Arterial Stiffness in Cardiovascular Risk Patients Without

Hiromitsu Sekizuka1, Satoshi Hoshide2, Tomoyuki Kabutoya2

  • 1Department of Internal Medicine, Fujitsu Clinic.

International Heart Journal
|December 2, 2021
PubMed

Insights

High triglyceride levels and diabetes are linked to arterial stiffness in individuals with cardiovascular risk factors. This study highlights their significant contribution to arterial stiffness, comparable to diabetes.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Metabolic Syndrome

Background:

  • Arterial stiffness is a key indicator of cardiovascular risk.
  • Limited data exist on the relationship between triglyceride levels and arterial stiffness.
  • Understanding these links is crucial for early intervention in at-risk populations.

Purpose of the Study:

  • To investigate the association between triglyceride levels and arterial stiffness.
  • To identify cardiovascular risk factors contributing to arterial stiffness.
  • To evaluate the predictive value of triglyceride levels for arterial stiffness.

Main Methods:

  • Analysis of data from 1,534 patients in the Coupling Registry with cardiovascular risk factors but no prior cardiovascular disease or LDL-C-lowering therapy.
  • Arterial stiffness assessed using the cardio-ankle vascular index (CAVI).
  • Statistical analysis including odds ratios and C-statistics to determine the association and predictive value of risk factors.

Main Results:

  • Higher triglyceride levels and diabetes were significantly associated with increased risk of arterial stiffness (higher CAVI).
  • Triglyceride levels showed an odds ratio of 1.26 per standard deviation increase.
  • Diabetes showed an odds ratio of 1.52 for higher CAVI.
  • Both triglyceride levels and diabetes significantly improved the prediction of arterial stiffness beyond age, sex, and BMI.

Conclusions:

  • Triglyceride levels are a significant, independent risk factor for arterial stiffness in patients with cardiovascular risk factors.
  • The contribution of triglyceride levels to arterial stiffness is comparable to that of diabetes.
  • Managing triglyceride levels may be important for preventing arterial stiffness in at-risk individuals.

Keywords:
AtherosclerosisCardio-ankle vascular indexCardiovascular diseaseDiabetes mellitusDyslipidemia

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