Related Experiment Videos
Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018
Tagwa A M Salih1, Bashir A Yousef1,2, Mohamed A M Salih3
1Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Khartoum, Khartoum, 11111, Sudan.
Insights
This study found that vancomycin use in a pediatric hospital often lacked adjustments based on culture data and proper monitoring. Improving vancomycin administration is crucial to combat antibiotic resistance.
Area of Science:
- Pharmacology
- Infectious Diseases
- Hospital Pharmacy
Background:
- Vancomycin is critical for hospital-acquired infections, especially Methicillin-resistant Staphylococcus aureus (MRSA).
- Rising vancomycin resistance necessitates careful drug utilization evaluation to ensure rational antibiotic use.
- Understanding current vancomycin prescribing practices is essential for antimicrobial stewardship.
Purpose of the Study:
- To evaluate the rational use of vancomycin in a pediatric hospital setting.
- To assess adherence to Hospital Infection Control Practices Advisory Committee (HICPAC) guidelines for vancomycin therapy.
- To identify areas for improvement in vancomycin prescribing and monitoring.
Main Methods:
- Retrospective review of 127 pediatric patient records over six months.
- Analysis of patient demographics, diagnoses, vancomycin dosage, and treatment duration.
- Assessment of vancomycin use against HICPAC guidelines and antibiotic therapy principles.
Main Results:
- Sepsis and pneumonia were the most frequent indications for vancomycin.
- Culture tests were obtained in only 20.5% of cases; serum creatinine monitoring in 81.1%.
- Appropriate vancomycin administration per HICPAC guidelines occurred in 67.7% of cases.
Conclusions:
- Vancomycin was frequently used empirically without subsequent adjustment based on culture results.
- Inadequate attention was paid to vancomycin infusion rates and serum creatinine monitoring.
- Optimizing vancomycin utilization requires better integration of diagnostic data and adherence to monitoring protocols.
Abstract:
Background: Vancomycin is an antibiotic of growing importance in the treatment of hospital-acquired infections; with a particular emphasis on its value in the fight against Methicillin-resistant Staphylococcus aureus. Increasing reports of Vancomycin resistance have raised concerns about the effectiveness of this drug. Drug utilization evaluation has an important role in controlling rational use of antibiotics to prevent the emergence of resistance. Methods: We conducted a retrospective 6-months study at Jafar Ibn Auf pediatric hospital. Data including patient's demographics, diagnosis, Dosage regimen, and treatment duration were reviewed. The concordance of practice with the Hospital Infection Control Practices Advisory Committee (HICPAC) guidelines and principles of antibiotic therapy was assessed. Results: 127 medical records were reviewed in this study. Sepsis (29%) and Pneumonia (19.6%) were the most common indications. Culture test was requested in 20.5% of patients. Monitoring of serum creatinine was carried in 81.1% of patients. Based on HICPAC guidelines vancomycin was administered appropriately in 67.7% percent of cases. Considering the infusion rate, most of patients with specific order were received vancomycin in 1 hour. Conclusions: The results showed that vancomycin was used empirically without subsequent adjustment of the antimicrobial agent according to culture and sensitivity data and lack of paying enough attention to the infusion rate and serum creatinine monitoring.