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Long Noncoding RNAs Involved in Cardiomyocyte Apoptosis Triggered by Different Stressors

Jinghui Sun1, Ru Wang1, Tiantian Chao1

  • 1National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Journal of Cardiovascular Translational Research
|December 2, 2021
PubMed

Insights

Long noncoding RNAs (lncRNAs) regulate cardiomyocyte apoptosis, a key factor in heart failure. Targeting these lncRNAs offers a promising new strategy for treating cardiovascular diseases.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Epigenetics

Background:

  • Cardiomyocytes are vital for heart function.
  • Pathological apoptosis of cardiomyocytes, induced by ischemia, hypoxia, or drugs, leads to heart failure and arrhythmia.
  • Understanding cardiomyocyte apoptosis mechanisms is crucial for cardiovascular disease prevention and treatment.

Purpose of the Study:

  • To explore the regulatory roles of long noncoding RNAs (lncRNAs) in myocardial cell apoptosis.
  • To investigate the potential of lncRNAs as therapeutic targets for cardiovascular diseases.

Main Methods:

  • Review of recent evidence on lncRNA involvement in cardiomyocyte apoptosis.
  • Analysis of lncRNA mechanisms including post-transcriptional gene modulation, miRNA precursor function, and miRNA-mediated inhibition competition.

Main Results:

  • lncRNAs significantly regulate cardiomyocyte apoptosis.
  • Abnormal lncRNA expression is linked to pathological apoptosis.
  • Reversing abnormal lncRNA expression can attenuate or reverse cardiomyocyte apoptosis.

Conclusions:

  • lncRNAs represent a novel regulatory layer in cardiomyocyte apoptosis.
  • Apoptosis-related lncRNAs offer a potential new avenue for studying and treating cardiovascular diseases.

Keywords:
ApoptosisCardiac functionCardiomyocyteLong noncoding RNA

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