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Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
370
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
245
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

466
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

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Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
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Related Experiment Video

Updated: Oct 11, 2025

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

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Microbe-based management for colorectal cancer.

Zi-Yun Gao1, Zhe Cui2, Yu-Qing Yan1

  • 1State Key Laboratory for Oncogenes and Related Genes; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health; Division of Gastroenterology and Hepatology; Shanghai Cancer Institute; Shanghai Institute of Digestive Disease; Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.

Chinese Medical Journal
|December 2, 2021
PubMed
Summary
This summary is machine-generated.

The gut microbiota influences colorectal cancer (CRC) development and outcomes. Modulating the intestinal bacteria offers novel therapeutic strategies for CRC prevention and treatment.

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Area of Science:

  • Microbiology
  • Oncology
  • Gastroenterology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally.
  • The intestinal microbiota plays a critical role in CRC pathogenesis and prognosis.
  • Dysbiosis, an imbalance in gut bacteria, is linked to CRC development.

Purpose of the Study:

  • To review the mechanisms of bacteria-derived colorectal carcinogenesis.
  • To summarize novel bacteria-related therapies for CRC.
  • To highlight the potential of gut microbiota modulation for CRC management.

Main Methods:

  • Literature review of studies on the gut microbiota and CRC.
  • Analysis of mechanisms linking specific bacteria to CRC.
  • Summary of emerging microbe-based therapeutic strategies.

Main Results:

  • Carcinogenic bacteria like enterotoxigenic Bacteroides fragilis (ETBF) and Streptococcus gallolyticus (S. gallolyticus) are implicated in CRC.
  • Protective bacteria such as Akkermansia muciniphila (A. muciniphila) show potential benefits.
  • Gut microbiota modulation strategies aim to restore balance and enhance immunity.

Conclusions:

  • Targeting the gut microbiota offers promising avenues for CRC prevention and treatment.
  • Probiotics, prebiotics, postbiotics, and fecal microbiota transplantation are novel therapeutic tools.
  • Further research can facilitate clinical applications of intestinal bacteria in CRC management.