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Calcium antagonist (PY 108-068) treatment may further decrease flow in ischemic areas in acute stroke.

S Vorstrup, A Andersen, N Blegvad

    Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
    |April 1, 1986
    PubMed
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    This study investigated PY 108-068, a new calcium antagonist, for acute ischemic stroke patients. The drug showed limited efficacy, with variable effects on cerebral blood flow (CBF) and no significant clinical improvement.

    Area of Science:

    • Neurology
    • Pharmacology
    • Cardiovascular Research

    Background:

    • Acute ischemic stroke poses a significant health challenge, necessitating novel therapeutic strategies.
    • Calcium antagonists are explored for their potential to improve cerebral blood flow (CBF) in stroke patients.

    Purpose of the Study:

    • To evaluate the effect of a novel calcium antagonist, PY 108-068, on regional cerebral blood flow (CBF) in patients with acute ischemic stroke.
    • To assess the safety and efficacy of PY 108-068 at two different intravenous dosage regimens.

    Main Methods:

    • The study involved two series of acute ischemic stroke patients receiving PY 108-068 intravenously at dosages of 1.5 + 2.5 mg (series 1, n=6) and 2.5 + 5.0 mg (series 2, n=5).
    • Cerebral blood flow (CBF) was measured using xenon-133 inhalation and single-photon emission computed tomography (Tomomatic 64) before and after treatment.

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  • Mean arterial blood pressure (MABP) and clinical symptoms were also monitored.

    • Main Results:

    • In series 1, no significant changes in hemispheric CBF, MABP, or clinical symptoms were observed, although one patient showed localized CBF increase in the periinfarct area.
    • Series 2 demonstrated slight increases in mean hemispheric flow, but three out of five patients experienced a further decrease in CBF within the ischemic area.
    • Mean arterial blood pressure (MABP) decreased by 13% in series 2, while clinical symptoms remained unchanged across both series.

    Conclusions:

    • The novel calcium antagonist PY 108-068 demonstrated limited therapeutic benefit in patients with acute ischemic stroke.
    • The drug exhibited variable effects on regional cerebral blood flow, with no consistent improvement and even further reductions in some ischemic areas.
    • Further research is needed to determine the potential role, optimal dosage, and specific patient populations that might benefit from PY 108-068 or similar agents in stroke management.