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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

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Periodontitis and Diabetes Complications: A Danish Population-Based Study.

F V Bitencourt^1,2, A Andersen², L Bjerg²

¹Section for Oral Ecology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.

Journal of Dental Research

|August 6, 2024

Summary

Diabetic neuropathy and retinopathy increase the risk of moderate/severe periodontitis. Dyslipidemia further elevates this risk, highlighting the combined impact of these conditions on oral health in diabetes patients.

Keywords:

diabetes mellitus diabetic foot diabetic neuropathies noncommunicable diseases oral health periodontal diseases

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Published on: February 17, 2023

Area of Science:

Endocrinology and Metabolism
Periodontology
Public Health

Background:

Conflicting evidence exists on the link between diabetes-related microvascular complications and periodontitis.
Previous studies were limited by small sample sizes and confounding factors.
The combined impact of microvascular complications and dyslipidemia on periodontitis remains unexplored.

Purpose of the Study:

To investigate the association between diabetic microvascular complications (neuropathy, retinopathy) and periodontitis.
To examine the combined effects of these complications on periodontitis risk.
To assess the modifying role of dyslipidemia in these associations.

Main Methods:

A population-based study of 15,922 individuals with type 2 diabetes from the Health in Central Denmark study.
Multinomial logistic regression and Inverse Probability of Treatment Weighting (IPTW) were used for analysis.
Sensitivity analyses were conducted to ensure robustness of findings.

Main Results:

Diabetic neuropathy (OR 1.36) and retinopathy (OR 1.21) were significantly associated with moderate/severe periodontitis.
The coexistence of microvascular complications increased periodontitis odds by 1.5-fold (OR 1.51).
Dyslipidemia showed a positive additive effect modification on the association between microvascular complications and periodontitis.

Conclusions:

Diabetic neuropathy and retinopathy, individually and combined, are associated with moderate/severe periodontitis.
Dyslipidemia exacerbates the risk of periodontitis in individuals with diabetic microvascular complications.
Findings can help identify at-risk populations for targeted interventions to reduce disease burden.