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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies.

Stéphane J C Mancini1,2,3, Karl Balabanian1,4,5, Isabelle Corre1,3,6

  • 1Centre National de la Recherche scientifique (CNRS) GDR3697, Micronit "Microenvironment of Tumor Niches", Tours, France.

Frontiers in Immunology
|December 3, 2021
PubMed
Summary
This summary is machine-generated.

This review explores how solid tumor research can illuminate the hematopoietic niche, particularly in blood cancers. Understanding tumor microenvironments offers new therapeutic targets beyond cancer stem cells.

Keywords:
angiogenesiscancer-associated fibroblasts (CAFs)cytokines and chemokinesendothelial plasticityenergy/oxidative metabolismmesenchymal stem/stromal cells (MSCs)microenvironmentmitochondrial transfer

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Area of Science:

  • Oncology
  • Hematology
  • Cancer Biology

Background:

  • Hematopoietic niche research has advanced via in vitro studies, mouse models, and xenografts.
  • Human bone marrow complexity, especially in hematological malignancies, is challenging to study.
  • Solid tumor research offers insights due to shared microenvironmental interactions and bone marrow metastasis.

Purpose of the Study:

  • To review recent discoveries in solid tumor niches applicable to hematopoietic niches.
  • To highlight key areas: fibroblast/stem cell heterogeneity, cytokines/chemokines, metabolism/communication, and the vascular niche.
  • To identify microenvironmental actors and pathways for improved cancer therapies.

Main Methods:

  • Literature review focusing on recent discoveries in solid tumor microenvironments.
  • Analysis of shared features between solid tumor niches and hematopoietic niches.
  • Examination of specific interactions: cell heterogeneity, signaling molecules, metabolism, and vascular dynamics.

Main Results:

  • Solid tumors and hematopoietic niches share microenvironmental components like mesenchymal, endothelial, and immune cells.
  • Heterogeneity of cancer-associated fibroblasts (CAFs) and mesenchymal stem/stromal cells (MSCs) is crucial.
  • Cytokines, chemokines, metabolic communication (e.g., mitochondrial transfer), and angiogenesis play significant roles.

Conclusions:

  • Insights from solid tumor niches can enhance understanding of hematopoietic niches in malignancy.
  • Targeting the tumor microenvironment, not just cancer stem cells, presents novel therapeutic strategies.
  • This approach may lead to improved treatments for blood cancers and other malignancies.