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Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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Traffic Light Commentary-Src in the Upside Down: A Kinase Turned Inside Out

Julie Gavard1,2,3, Quentin Roux1,2

  • 1CRCI2NA, Inserm, CNRS, Université de Nantes, Nantes, France.

Traffic (Copenhagen, Denmark)
|June 22, 2026
PubMed
Summary

Topological inversion of Src kinase reveals its unexpected extracellular role in cancer signaling. This discovery offers new insights into kinase signaling pathways and potential cancer therapies.

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