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Pharmacological Treatment Options for Coronavirus Disease-19 in Renal Patients

Jonny1, Laurencia Violetta1, Arief Sjamsulaksan Kartasasmita2

  • 1Nephrology Division, Department of Internal Medicine, Gatot Soebroto Indonesia Army Central Hospital, Jakarta, Indonesia.

International Journal of Nephrology
|December 3, 2021
PubMed

Insights

Patients with chronic kidney disease (CKD) need specific COVID-19 drug guidance. This review details necessary dosage adjustments and renal side effects for managing SARS-CoV-2 in kidney patients.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • Patients with chronic kidney disease (CKD) face increased risk from SARS-CoV-2 infection.
  • Existing comorbidities in CKD patients exacerbate COVID-19 severity.
  • No specific guidelines exist for managing COVID-19 in renal impairment.

Purpose of the Study:

  • To review dosing adjustments for COVID-19 drugs in patients with kidney dysfunction.
  • To identify potential renal side effects of common COVID-19 treatments.
  • To inform nephrologists on optimizing SARS-CoV-2 management in CKD.

Main Methods:

  • Non-systematic review of COVID-19 treatments.
  • Exploration of clinical trial databases and search engines.
  • Analysis of drug information for renal dosing and side effects.

Main Results:

  • Several antivirals and monoclonal antibodies require dosage modification for kidney dysfunction.
  • Monitoring for renal side effects is crucial with combined drug therapies.
  • Optimal therapeutic effects depend on careful dose titration based on renal function.

Conclusions:

  • Nephrologists must carefully adjust COVID-19 drug dosages based on renal function.
  • Close monitoring for renal side effects is essential to prevent further kidney damage.
  • Further research is needed to establish safety and efficacy in renal patients.

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