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Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Related Experiment Video

Updated: Oct 11, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

Digital ocular swept source optical coherence aberrometry.

Stefan Georgiev^1,2,3, Abhishek Kumar^1,4,3, Oliver Findl²

¹Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.

Biomedical Optics Express

|December 3, 2021

Summary

This summary is machine-generated.

This study introduces a novel swept source optical coherence tomography (SS-OCT) system for precise ocular aberrometry. The technique offers high-speed, in-vivo measurements for advanced vision science applications.

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Area of Science:

Ophthalmology
Vision Science
Optical Engineering

Background:

Ocular aberrometry is crucial for understanding visual optics.
Existing methods may have limitations in speed or scope.
Digital adaptive optics (DAO) offers potential for enhanced aberrometry.

Purpose of the Study:

To demonstrate a phase-sensitive SS-OCT system for quantitative ocular aberrometry.
To assess the feasibility and repeatability of the developed technique.

Main Methods:

Utilized a phase-sensitive single mode fiber-based swept source optical coherence tomography (SS-OCT) setup.
Employed digital adaptive optics (DAO) and a guide star pencil beam.
Recorded volumetric point spread function at the retina in a de-scanning geometry.

Main Results:

Achieved test-retest repeatability assessment for defocus and astigmatism.
Demonstrated feasibility in-vivo within a ±3 D dynamic range.
Operated at a B-scan rate exceeding 1 kHz, outperforming commercial aberrometers.

Conclusions:

The developed SS-OCT system provides a viable and efficient method for ocular aberrometry.
This technique advances quantitative vision analysis and ophthalmological diagnostics.
High-speed, in-vivo aberrometry opens new avenues for research and clinical applications.