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Liver Involvement in SARS-CoV-2 Vertically Infected Newborn: A Case Report
Ilaria Stolfi1, Maria Giulia Conti1,2, Alessandra Marciano1
1Department of Maternal and Child Health, Sapienza University of Rome, Rome, Italy.
Neonatal SARS-CoV-2 infection, often subclinical, can manifest with diverse symptoms. This case highlights vertical transmission presenting as liver injury with elevated transaminases in newborns.
Area of Science:
- Neonatology
- Virology
- Hepatology
Background:
- Neonatal SARS-CoV-2 infection can occur via antenatal, peripartum, or postnatal transmission.
- Clinical presentations in newborns range from asymptomatic to fever, respiratory, gastrointestinal, and neurological symptoms.
Observation:
- A case of vertical transmission of SARS-CoV-2 in a neonate is presented.
- The neonate exhibited liver injury.
Findings:
- Liver injury was characterized by a significant increase in serum transaminases.
- This suggests SARS-CoV-2 can directly impact the neonatal liver.
Implications:
- Highlights the potential for neonatal liver injury due to SARS-CoV-2 vertical transmission.
- Emphasizes the need for monitoring liver function in neonates with confirmed SARS-CoV-2 infection.
- Contributes to understanding the spectrum of clinical manifestations of COVID-19 in newborns.
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