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Targeting the immune microenvironment during immunotherapy for solid tumors

Aiman Sabaawy1, Saman Zeeshan1

  • 1Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.

Molecular & Cellular Oncology
|December 3, 2021
PubMed

JAK/STAT signaling is a central hub in cancer development, progression, immunosurveillance and response to immunotherapy. We discuss recent advances in the role of the JAK/STAT pathway in immunotherapies. We stress the importance of fully understanding how JAK/STAT modifies the immune response before implementing clinical trials combining JAK/STAT inhibitors with immunotherapy.

Keywords:
JAK/STAT pathwayimmune checkpoint inhibitorsimmunotherapysolid tumorstumor microenvironment

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