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An association between HLA DRI and lichen planus.
The British Journal of Dermatology
|April 1, 1986
Summary
Lichen planus (LP) is strongly associated with specific human leukocyte antigen (HLA) Class II genes, particularly HLA DR1 and MTI (DQW1). This suggests a genetic susceptibility to developing generalized and drug-induced lichen planus.
Area of Science:
- Immunogenetics
- Dermatology
Background:
- Lichen planus (LP) is an inflammatory condition affecting skin and mucous membranes.
- The role of human leukocyte antigen (HLA) Class II antigens in LP pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the association between HLA Class II antigens and different forms of lichen planus.
- To identify potential genetic markers for LP susceptibility.
Main Methods:
- Serological typing was performed on 72 patients diagnosed with lichen planus.
- HLA Class II antigen frequencies were compared between LP patients and healthy controls.
Main Results:
- A significant association was found between lichen planus and HLA DR1 (DRI) and MTI (DQW1).
- HLA DRI was notably prevalent in generalized LP (80%) and drug-induced LP (56%) compared to controls (25%).
- MTI (DQW1) was found in 83% of LP patients versus 62% of controls.
Conclusions:
- The study strongly suggests a genetic predisposition to lichen planus, particularly generalized and drug-induced forms.
- HLA Class II antigens, specifically DRI and MTI (DQW1), may play a role in LP susceptibility.