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Updated: Oct 11, 2025
Cryosectioning Method for Microdissection of Murine Colonic Mucosa
Published on: July 12, 2015
[A new look at colonic mucosal structural rearrangement and the stages of chronic colitis]
Kh M Akhrieva1, E A Kogan2, A S Tertychnyi2
1Ingush State University, Makhachkala, Russia.
Objective:
To revise the existing criteria to improve the definition of chronic colitis stages in inflammatory bowel diseases (IBDs).
Material And Methods:
A total of 100 cases of IBDs (ulcerative colitis (n=70) and Crohn's disease (n=30) diagnosed in 2017 to 2019 were examined. Thirty patients with colitis were selected for a comparison group, who were assigned to an infective colitis group or a drug-induced colitis one at the final diagnosis.
Results:
The sequence of chronic colitis stages was defined from Stage 1 (early changes) to Stage 3, which are characterized by progressive mucosal structural rearrangement. Mainly at Stage 3 that characterizes the final stage of structural rearrangement in the mucous membrane, where dysplastic changes (the onset of tumor transformation) are detected.
Conclusion:
For the diagnosis of chronic colitis in IBD, it is mandatory to detect mucosal structural rearrangement. Stages 1 and 2 are characterized by early structural changes in the mucous membrane, whereas the process becomes irreversible at Stage 3. The identification of colitis stages is of diagnostic and, undoubtedly, prognostic value.
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