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Lurasidone Ingestions Reported to Texas Poison Centers.

Mathias B Forrester1

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The Journal of Pharmacy Technology : Jpt : Official Publication of the Association of Pharmacy Technicians
|December 3, 2021
PubMed
Summary

Lurasidone ingestions in Texas primarily involved adults and females, often due to suspected suicide attempts. Most cases without other substances had non-serious outcomes.

Keywords:
atypical antipsychoticlurasidonemanagementoutcomepoison center

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Area of Science:

  • Toxicology
  • Pharmacovigilance
  • Public Health

Background:

  • Lurasidone, an atypical antipsychotic approved in 2010, has limited data on toxic events outside clinical trials.
  • This study addresses the gap in knowledge regarding lurasidone's toxicity in real-world ingestion cases.

Purpose of the Study:

  • To characterize potentially toxic lurasidone ingestions reported to poison centers.
  • To analyze patient demographics, exposure circumstances, management, and outcomes of lurasidone ingestions.

Main Methods:

  • Retrospective analysis of lurasidone ingestions reported to Texas poison centers from 2011 to 2013.
  • Data collected included patient characteristics, dose, reason for exposure, coingestants, management site, and medical outcomes.
  • Analysis focused on cases without coingestants for management and outcome factors.

Main Results:

  • 140 lurasidone ingestions were reported; 54.3% were suspected suicide attempts.
  • The majority of patients were adults (70.7%) and female (65.7%).
  • In cases without coingestants (n=55), 65.5% had non-serious outcomes, with drowsiness, agitation, and nausea being common effects.

Conclusions:

  • Lurasidone ingestions reported to poison centers predominantly involved adult females, with a high proportion linked to suicide attempts.
  • While many ingestions involved coingestants, cases without them generally resulted in non-serious medical outcomes.
  • Findings highlight the need for monitoring and understanding lurasidone's toxicity profile in overdose scenarios.