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Pattern of Mefloquine Ingestions Reported to Texas Poison Centers
1Texas Department of State Health Services, Austin, TX, USA.
Mefloquine ingestions reported to Texas poison centers were infrequent, primarily affecting adult males due to therapeutic errors or adverse reactions. Most cases had minor outcomes, with few serious neurological or psychiatric effects observed.
Area of Science:
- Pharmacovigilance
- Toxicology
- Public Health
Background:
- Mefloquine, an antimalarial drug, carries a black box warning for potential neurologic and psychiatric adverse effects.
- This study examines mefloquine ingestions reported to poison control centers in Texas.
Purpose of the Study:
- To characterize mefloquine ingestions reported to Texas poison centers between 2010 and 2014.
- To analyze demographic, exposure, and outcome data for these ingestions.
Main Methods:
- Retrospective analysis of 63 mefloquine ingestion cases reported to Texas poison centers (2010-2014).
- Data collected included dose, patient demographics, exposure circumstances, management, clinical effects, and outcomes.
Main Results:
- The mean mefloquine dose was 672 mg; 58.7% of patients were adults, and 52.4% were male.
- Therapeutic errors (71.4%) and adverse reactions (19.0%) were the main reasons for ingestion.
- Most outcomes were not serious (79.4%), with common effects being gastrointestinal (28.6%) and neurological (20.6%).
Conclusions:
- Mefloquine ingestions reported in Texas were uncommon, predominantly involving adult males.
- While serious side effects are possible, reported cases typically had minor outcomes and were managed outside healthcare facilities.
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