Related Experiment Video
Updated: Oct 11, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
Digital Medicine: Innovative Drug-Device Combination as New Measure of Medication Adherence
Ximena Vallejos1, Christine Wu1
1Miami VA Healthcare System, Miami, FL, USA.
Abstract:
In September 2015, the Food and Drug Administration accepted the first digital medicine new drug application for a drug-device combination of Otsuka's Abilify® (aripiprazole) and an ingestible sensor embedded in the tablet that digitally records ingestion. When this digital medicine is taken, it sends a signal to a patch worn by the patient. The information is recorded, time-stamped, and relayed to any Bluetooth-enabled device and, with patients' consent, to their physicians and/or their caregivers. An encapsulation model in which a tablet is co-encapsulated with the ingestible sensor has been successfully used in the setting of renal transplant, diabetes, hypertension, and hypercholesterolemia.
Related Concept Videos
Drug Therapy
Antianxiety Medications
Therapeutic Drug Monitoring: Overview and Classification
Therapeutic Drug Monitoring: Drug Analysis Methods
Measurement of Bioavailability: Pharmacodynamic Methods
Therapeutic Drug Monitoring: Affecting Factors
Dosage Regimen: Individualization

