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Mycobacterium leprae found in epidermal cells by electron microscopy
Summary
Leprosy bacilli can be present in skin keratinocytes, even without visible ulcers. This finding suggests potential leprosy bacilli shedding from the skin of affected individuals.
Area of Science:
- Dermatology
- Microbiology
- Pathology
Background:
- Leprosy, a chronic infectious disease, primarily affects the skin and peripheral nerves.
- Understanding the transmission routes of Mycobacterium leprae is crucial for disease control.
Purpose of the Study:
- To investigate the presence of leprosy bacilli within epidermal keratinocytes.
- To assess the potential for leprosy bacilli shedding from non-ulcerated skin.
Main Methods:
- Electron microscopic examination of ultrathin sections of leproma tissue.
- Histopathological analysis of skin biopsies.
Main Results:
- Leprosy bacilli were identified within an epidermal keratinocyte.
- The presence of bacilli was confirmed in the absence of skin ulceration.
Conclusions:
- Leprosy bacilli can reside in epidermal keratinocytes.
- Skin shedding of leprosy bacilli is possible even in patients without apparent skin lesions, highlighting a potential transmission pathway.