Related Experiment Video
Updated: Oct 11, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Epigenetic Modifications and Therapy in Uveitis
Yanli Zou1,2, Jing Jing Li2, Wei Xue2
1Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical University, Foshan, China.
Abstract:
Uveitis is a sight-threatening intraocular inflammation, and the exact pathogenesis of uveitis is not yet clear. Recent studies, including multiple genome-wide association studies (GWASs), have identified genetic variations associated with the onset and progression of different types of uveitis, such as Vogt-Koyanagi-Harada (VKH) disease and Behcet's disease (BD). However, epigenetic regulation has been shown to play key roles in the immunoregulation of uveitis, and epigenetic therapies are promising treatments for intraocular inflammation. In this review, we summarize recent advances in identifying epigenetic programs that cooperate with the physiology of intraocular immune responses and the pathology of intraocular inflammation. These attempts to understand the epigenetic mechanisms of uveitis may provide hope for the future development of epigenetic therapies for these devastating intraocular inflammatory conditions.
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Chromatin Modification in iPS Cells
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
iPS Cell Differentiation
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...

