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Related Experiment Videos

Histamine as endogenous immunomodulator.

R Eckert, H Repke

    Methods and Findings in Experimental and Clinical Pharmacology
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Histamine, through H2-receptors, influences T-cell dependent immune responses, acting as both a suppressive and enhancing immunomodulator. Its effects vary across mouse strains, indicating complex immune regulation.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Cellular Biology

    Background:

    • Histamine is known to modulate immune responses.
    • The specific mechanisms by which histamine influences T-cell dependent antibody production are not fully elucidated.
    • Histamine receptors, particularly H2-receptors, are implicated in immune cell function.

    Purpose of the Study:

    • To investigate the role of histamine in T-cell dependent antibody production.
    • To determine whether histamine acts as an immunosuppressive or immunostimulatory agent on the humoral immune response.
    • To explore the influence of H2-receptor interaction in histamine's immunomodulatory effects.

    Main Methods:

    • In vitro histamine treatment of cells or lymphokine preparations.
    • Transfer of treated cells/preparations into recipient mice.

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  • Characterization of the humoral immune response in recipient mice.
  • Assessment of histamine concentrations and their effects across different mouse strains.

    • Main Results:

    • Histamine treatment induced the production of both suppressive and enhancing factors.
    • These effects were mediated via histamine's interaction with H2-receptors.
    • Effective histamine concentrations varied significantly among different mouse strains.
    • The study demonstrated histamine's dual role in modulating the humoral immune response.

    Conclusions:

    • Histamine acts as a dual immunomodulator, capable of both suppressing and enhancing humoral immune responses in vivo.
    • The observed strain-specific differences highlight a complex regulatory network involving histamine.
    • The findings suggest histamine's significant role in the intricate balance of immune system function.