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Updated: Oct 11, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Preemptive local analgesia at vaginal hysterectomy: a systematic review
Nadja Taumberger1, Anna-Maria Schütz2, Klaus Jeitler3
1Department of Obstetrics & Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria. nadja.taumberger@medunigraz.at.
Introduction And Hypothesis:
We conducted a systematic review of the effectiveness of local preemptive analgesia for postoperative pain control in women undergoing vaginal hysterectomy.
Methods:
MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews were searched systematically to identify eligible studies published through September 25, 2019. Only randomized controlled trials and systematic reviews addressing local preemptive analgesia compared to placebo at vaginal hysterectomy were considered. Data were extracted by two independent reviewers. Results were compared, and disagreement was resolved by discussion. Forty-seven studies met inclusion criteria for full-text review. Four RCTs, including a total of 197 patients, and two SRs were included in the review.
Results:
Preemptive local analgesia reduced postoperative pain scores up to 6 h and postoperative opioid requirements in the first 24 h after surgery.
Conclusion:
Preemptive local analgesia at vaginal hysterectomy results in less postoperative pain and less postoperative opioid consumption.
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