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Related Concept Videos

Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
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Determination01:51

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Yeast Signaling01:28

Yeast Signaling

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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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Overview of Cell Signaling01:23

Overview of Cell Signaling

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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Updated: Oct 11, 2025

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
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Signalling dynamics in embryonic development.

Katharina F Sonnen1, Claudia Y Janda2

  • 1Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), University Medical Center Utrecht, Utrecht, The Netherlands.

The Biochemical Journal
|December 6, 2021
PubMed
Summary
This summary is machine-generated.

Cellular communication via signaling pathways is crucial for development and health. Dynamic signaling patterns, like those in Erk, Wnt, and Notch pathways, influence cell behavior and organism development, with dysregulation linked to cancer.

Keywords:
Erk signallingNotch signallingWnt signallingembryonic developmentsignallingsignalling dynamics

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Area of Science:

  • Cellular and Molecular Biology
  • Developmental Biology
  • Systems Biology

Background:

  • Cellular behavior in multicellular organisms is tightly regulated by intercellular communication through signaling pathways.
  • Errors in cell communication can lead to developmental defects and diseases, including cancer.
  • Signaling pathway activity is dynamic, exhibiting temporal variations like transient activation, ramping, or oscillations.

Purpose of the Study:

  • To explore the dynamics of Erk, Wnt, and Notch signaling pathways.
  • To understand how biochemical processes influence the dynamics of these pathways.
  • To investigate the impact of signaling dynamics on cellular behavior in multicellular systems.

Main Methods:

  • Focus on Erk, Wnt, and Notch signaling pathways.
  • Analysis of dynamic phenotypes (e.g., transient activation, oscillations).
  • Examination of cell type- and stage-dependent signaling variations.

Main Results:

  • Signaling pathway dynamics are essential for robust and reproducible embryonic development.
  • Specific dynamics observed in Erk, Wnt, and Notch pathways are implicated in tissue types and organisms.
  • Dysregulation of these dynamic pathways is frequently observed in cancer.

Conclusions:

  • The temporal dynamics of signaling pathways are critical for proper cellular function and organismal development.
  • Understanding these dynamics provides insights into developmental robustness and disease mechanisms.
  • Biochemical control of signaling dynamics significantly impacts multicellular systems.