Related Experiment Video
Updated: Oct 11, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Hyperuricemia as a possible risk factor for abnormal lipid metabolism in the Chinese population: a cross-sectional
Shaohong Zhang1, Yingchai Zhang2, Shuangjie Lin3
1Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Department of Geriatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
Background:
Previous studies have reported that there may be a close relationship between elevated serum uric acid (UA) levels and metabolic syndrome. However, the association between these two factors has not been explored explicitly. Therefore, we carried out this study to investigate the association between UA and lipid profiles.
Methods:
A total of 2,482 subjects participated in this cross-sectional study using a multistage stratified sampling method. Lipid profile, glucose metabolism, and other metabolic factors were measured and classified into UA-stratified and age-stratified groups to investigate the relationship between hyperuricemia and metabolic factors. Pearson correlations and logistic regressions were utilized to further explore the association between UA and lipid profile.
Results:
The individuals aged 18 to 29 years presented with high serum UA concentrations. Moreover, the prevalence of hyperuricemia was higher among men than in women. Furthermore, statistically significant positive correlations were found between UA and serum triglycerides (TG), serum total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c). Conversely, only high-density lipoprotein cholesterol (HDL-c) was negatively correlated. Moreover, TG group status (1.70≤ TG <2.30 mmol/L) was an independent risk factor for hyperuricemia in both univariate and multivariate models.
Conclusions:
This study found significant positive associations between TG, TC, LDL, and UA but an inverse relationship with HDL-c. Thus hyperuricemia may be a risk factor for abnormal lipid metabolism.
Related Concept Videos
Cholesterol: Significance and Regulation
Considering cholesterol and...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Lipids: Dietary Sources and Requirements
Lipid-Lowering Drugs: Statins and Miscellaneous Agents

