Related Experiment Video

Updated: Oct 11, 2025

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
07:49

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

2.7K

Somatic mitochondrial DNA mutations in different grades of glioma

Bee Hong Soon1,2, Nadiah Abu1, Nor Azian Abdul Murad1

  • 1UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.

Personalized Medicine
|December 7, 2021
PubMed

Insights

Mitochondrial DNA (mtDNA) mutations are common in brain gliomas, with 45% being pathogenic. These findings offer insights into cancer development and potential therapeutic targets.

Area of Science:

  • Oncology
  • Genetics
  • Neuroscience

Background:

  • Mitochondrial DNA (mtDNA) alterations are implicated in cancer development.
  • Gliomas are a common type of brain cancer, but the role of mtDNA alterations in their progression is not fully understood.

Purpose of the Study:

  • To investigate the profile of somatic mtDNA mutations across different grades of gliomas.
  • To correlate these mtDNA alterations with the clinical characteristics of glioma patients.

Main Methods:

  • Sequencing of mitochondrial DNA (mtDNA) from 40 glioma tissue samples and matched blood.
  • Histopathological confirmation of all glioma samples.

Main Results:

  • Somatic mtDNA mutations were identified in approximately 75% of gliomas.
  • 45% of the detected mtDNA mutations were classified as pathogenic.
  • Mutations were distributed throughout the mtDNA genome, frequently affecting genes in mitochondrial respiratory chain complexes I and IV.

Conclusions:

  • Somatic mtDNA mutations are prevalent in gliomas and can be pathogenic.
  • The identified mutation patterns may influence mitochondrial function and cellular metabolism in gliomas.
  • Further research into mitochondrial energetics and metabolomics in gliomas is warranted.
Keywords:
MalaysiacancergenomeglioblastomagliomasmicroarraymitochondriamtDNAmutationsomatic mutation

More Related Videos

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells11:13

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

Published on: February 22, 2017

13.2K
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.0K

Related Concept Videos

Mutations01:39

Mutations

Overview
85.4K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
8.2K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
13.2K