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Updated: Oct 11, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
A β-hairpin peptide with pH-controlled affinity for tumor cells
Shin-Nosuke Nishimura1, Kei Nishida1, Masaru Tanaka1
1Institute for Materials Chemistry and Engineering, Kyushu University, 744, Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan. shinnosuke_nishimura@ms.ifoc.kyushu-u.ac.jp.
Abstract:
Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.
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