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Updated: Aug 11, 2026

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein
Published on: April 21, 2015
Low responder MHC alleles for Tc recognition of influenza nucleoprotein
Abstract:
Since virus nucleoprotein is an important target antigen for anti-influenza cytotoxic T cells (Tc), we examined the genetics of Tc responses to this single viral protein to find three nonresponder alleles (Dd, Dk, and Kb) in three haplotypes and their recombinants so far tested. B10.A(5R) mice bearing nonresponder MHC class I antigen in the D and K regions show no anti-NP Tc responses, however they do show a strong A-virus cross-reactive anti-influenza cytotoxicity. The high frequency of nonresponsiveness to a single viral component, as compared with the entire virus, has implications for the development of simple vaccines.
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