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Updated: Oct 10, 2025
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Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
395
Virus infection induced pulmonary fibrosis
Wei Jie Huang1, Xiao Xiao Tang2,3
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Journal of Translational Medicine
|December 8, 2021
Summary
Virus infections, including SARS-CoV-2, are increasingly linked to pulmonary fibrosis. Understanding these mechanisms is crucial for developing new anti-fibrotic therapies for viral lung diseases.
Area of Science:
- Pulmonology
- Virology
- Pathology
Background:
- Pulmonary fibrosis is a severe outcome of diverse interstitial lung diseases.
- Over 200 factors contribute to fibrosis, with viral infections gaining attention.
- Mechanisms of virus-induced pulmonary fibrosis, especially post-SARS-CoV-2, require further elucidation.
Purpose of the Study:
- To review the association between various viral infections and pulmonary fibrosis.
- To explore the underlying mechanisms of virus-induced pulmonary fibrosis.
- To identify potential therapeutic targets for anti-fibrotic treatments.
Main Methods:
- Literature review of studies on viral infections and pulmonary fibrosis.
- Analysis of mechanisms linking viruses like HTLV, HIV, CMV, EBV, MHV-68, Influenza, MERS-CoV, SARS-CoV, and SARS-CoV-2 to fibrosis.
- Synthesis of current knowledge on virus-host interactions in fibrotic lung disease.
Main Results:
- Multiple viruses, including SARS-CoV-2, are implicated in the development of pulmonary fibrosis.
- Specific viral factors and host responses contribute to fibrotic processes in the lungs.
- The review consolidates evidence linking viral infections to interstitial lung disease progression.
Conclusions:
- Viral infections represent a significant, yet not fully understood, cause of pulmonary fibrosis.
- Understanding these mechanisms can guide the development of novel anti-fibrotic strategies.
- Targeting virus-specific pathways may offer new therapeutic avenues for treating viral-induced pulmonary fibrosis, including that caused by SARS-CoV-2.
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