Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T cell subsets in human colostrum.

M A Keller, J Faust, L J Rolewic

    Journal of Pediatric Gastroenterology and Nutrition
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Update on programs for achieving Specialist in Blood Banking certification in the United States: 2023.

    Immunohematology·2023
    Same author

    Novel <i>KEL</i> allele associated with loss of Kp<sup>b</sup> identified in a white blood donor.

    Immunohematology·2022
    Same author

    New <i>ABO</i> intron 1 variant alleles.

    Immunohematology·2021
    Same author

    Assessment of common red blood cell pretreatments to yield an accurate serologic antigen phenotype compared with genotype-predicted phenotype.

    Immunohematology·2021
    Same author

    Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the <i>JK</i> gene.

    Immunohematology·2021
    Same author

    Two small, cysteine-rich and cationic antifungal proteins from Penicillium chrysogenum: A comparative study of PAF and PAFB.

    Biochimica et biophysica acta. Biomembranes·2020
    Same journal

    Foreign body ingestions in children and adolescents: A position paper of the ESPGHAN endoscopy special interest group.

    Journal of pediatric gastroenterology and nutrition·2026
    Same journal

    Abdominal pain in pediatric immunoglobulin A vasculitis: Risk factors and severity predictors in a multicenter cohort.

    Journal of pediatric gastroenterology and nutrition·2026
    Same journal

    Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition.

    Journal of pediatric gastroenterology and nutrition·2026
    Same journal

    Safety of infant milks: Contamination with cereulide. A commentary by ESPGHAN (European Society for Paediatric Gastroenterology, Hepatology, and Nutrition).

    Journal of pediatric gastroenterology and nutrition·2026
    Same journal

    ESPGHAN position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease.

    Journal of pediatric gastroenterology and nutrition·2026
    Same journal

    Treatment outcomes and determinants of refractory peptic ulcer disease in children: A prospective study from Vietnam.

    Journal of pediatric gastroenterology and nutrition·2026
    See all related articles

    Colostrum contains T cells, a type of lymphocyte, with a subset distribution similar to peripheral blood. However, colostrum shows a statistically significant lower percentage of OKT8 positive T cells compared to blood.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Colostrum, the first milk produced after birth, plays a crucial role in neonatal immunity.
    • T lymphocytes are key components of the adaptive immune system, mediating cellular immunity.

    Purpose of the Study:

    • To investigate potential differences in T cell subset distribution between human colostrum and peripheral blood.
    • To determine if the T cell population in colostrum is selectively enriched or depleted compared to systemic circulation.

    Main Methods:

    • Paired specimens of colostrum and peripheral blood were collected from 10 mothers.
    • Flow cytometry was used to quantify T cell subsets (OKT3+, OKT4+, OKT8+) via murine monoclonal antibody staining.

    Main Results:

    • Colostrum T cells showed percentages: 74.7% OKT3+, 50.6% OKT4+, 24.0% OKT8+.

    Related Experiment Videos

  • Peripheral blood T cells showed percentages: 78.7% OKT3+, 48.4% OKT4+, 29.8% OKT8+.
  • A statistically significant lower percentage of OKT3+ and OKT8+ T cells was observed in colostrum compared to peripheral blood (p<0.05 and p<0.01, respectively).

    • Conclusions:

    • While generally similar, the T cell subset distribution in colostrum differs slightly from peripheral blood.
    • The observed differences, particularly in OKT8+ T cells, suggest potential selectivity in the transport or retention of T cells in colostrum.