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Updated: Oct 10, 2025

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Published on: August 7, 2011

Research-Relevant Clinical Pathology Resources: Emphasis on Mice, Rats, Rabbits, Dogs, Minipigs, and Non-Human

Liza Bau-Gaudreault¹, Tara Arndt², Anne Provencher³

¹Clinical Laboratories, Charles River Laboratories - ULC, Senneville, Quebec, Canada.

|December 8, 2021

Summary

This summary is machine-generated.

This review details clinical pathology testing in laboratory animals for research and safety assessments. It emphasizes understanding species-specific variables for accurate interpretation of results.

Keywords:

Clinical chemistry clinical pathology coagulation cytology hematology laboratory animal safety assessment toxicology

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Area of Science:

Veterinary Medicine
Toxicology
Biomedical Research

Background:

Clinical pathology is crucial for research and safety evaluations in laboratory animals.
Accurate interpretation requires understanding species-specific variables and influential factors.
This field is a distinct specialty for researchers, toxicologists, and pathologists.

Purpose of the Study:

To provide a comprehensive resource on clinical pathology principles for laboratory animal species.
To offer testing recommendations for researchers and veterinary specialists.
To aid toxicologists and pathologists in interpreting preclinical safety data.

Main Methods:

Review of existing literature on clinical pathology in laboratory animals.
Compilation of principles and best practices for testing.
Synthesis of species-specific considerations for data interpretation.

Main Results:

Established key principles for effective clinical pathology testing in research animals.
Provided recommendations for standardized testing protocols.
Highlighted the importance of considering numerous variables influencing test outcomes.

Conclusions:

Clinical pathology in laboratory animals is a specialized field requiring expert knowledge.
This review serves as a valuable resource for improving research and safety assessment accuracy.
Understanding species-specific factors is paramount for reliable toxicological and biomedical studies.