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[COVID-19, anticoagulation and venous thromboembolism: what have we learned ?]

Marc Blondon1, Helia Robert-Ebadi1

  • 1Service d'angiologie et d'hémostase, Hôpitaux universitaires de Genève, 1211 Genève 14.

Revue Medicale Suisse
|December 8, 2021
PubMed

Insights

COVID-19 patients face thrombotic risks. For critically ill patients, standard prophylactic anticoagulation is recommended, while therapeutic anticoagulation benefits for non-critical cases require further study.

Area of Science:

  • Internal Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Severe COVID-19 is linked to venous thromboembolism and immuno-thrombotic issues, causing lung vascular damage.
  • Understanding thrombotic risk factors and anticoagulation strategies is crucial for managing COVID-19 inpatients.

Purpose of the Study:

  • To review current knowledge on thrombotic risk in COVID-19 inpatients.
  • To summarize predictive factors for thrombosis, including D-dimer levels.
  • To analyze randomized trials on anticoagulation's impact on clinical and thrombotic outcomes.

Main Methods:

  • Literature review of thrombotic risk in COVID-19.
  • Analysis of predictive factors for thromboembolism.
  • Evaluation of randomized controlled trials on anticoagulation in COVID-19 patients.

Main Results:

  • Therapeutic anticoagulation did not improve clinical prognosis in critically ill COVID-19 inpatients.
  • Standard prophylactic anticoagulation is recommended for critically ill patients.
  • Therapeutic anticoagulation may reduce severe deterioration risk in non-critical COVID-19 cases, but requires further validation.

Conclusions:

  • Standard prophylactic anticoagulation is the recommended approach for critically ill COVID-19 patients.
  • The role of therapeutic anticoagulation in non-critical COVID-19 inpatients needs further investigation through ongoing studies and meta-analyses.

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