Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.9K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.9K
Feedback Inhibition00:46

Feedback Inhibition

55.4K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
55.4K
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

8.7K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
8.7K
GPCR Desensitization01:12

GPCR Desensitization

6.7K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
6.7K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

13.0K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
13.0K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

4.9K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interrupting the perception-action cycle reshapes serial dependence and sensory processing.

Brain research·2026
Same author

Alpha phase coding supports feature binding during working memory maintenance.

Communications biology·2026
Same author

Sensorimotor dynamics differentiate singing and speaking.

bioRxiv : the preprint server for biology·2026
Same author

What is next? Predictable visual sequences are encoded with anticipatory biases and reduced neural responses.

iScience·2026
Same author

Large-scale mega-analysis indicates that serial dependence deteriorates perceptual decision-making.

Nature human behaviour·2025
Same author

An integrative approach to the study of drift-diffusion dynamics in working memory.

Neuron·2025
Same journal

Investigating the Neural Origins of Ear-EEG: A Correlation Study Using Scalp EEG Source Reconstruction.

NeuroImage·2026
Same journal

Hysteresis effects in visual and auditory perception and the comparison of underlying neural mechanisms - an EEG study.

NeuroImage·2026
Same journal

Short-term audio-tactile training affects cortical auditory speech-envelope tracking for incongruent but not congruent stimuli.

NeuroImage·2026
Same journal

Dissociable Neurocognitive Mechanisms of State and Trait Anxiety in Working Memory: Threat-Induced Alterations in Decision Dynamics and Attenuation of Large-Scale Network Reconfiguration.

NeuroImage·2026
Same journal

Neuro-Ocular Amyloid Characterization in Alzheimer's Disease via Cross-Site PET-MRI and Hierarchical Cross-Attention Driven Multimodal Representation Learning.

NeuroImage·2026
Same journal

Whole-brain network dynamics underlying intolerance of uncertainty.

NeuroImage·2026
See all related articles

Related Experiment Video

Updated: Oct 10, 2025

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.3K

Selective attention involves a feature-specific sequential release from inhibitory gating.

Mattia F Pagnotta1, David Pascucci2, Gijs Plomp1

  • 1Perceptual Networks Group, Department of Psychology, University of Fribourg, Fribourg, Switzerland.

Neuroimage
|December 8, 2021
PubMed
Summary
This summary is machine-generated.

This study reveals how selective attention prioritizes visual information by dynamically modulating brain network connectivity. Alpha-band oscillations in the brain help filter distractions, enabling faster processing of relevant sensory input.

Keywords:
Alpha rhythmFeature-based attentionFunctional connectivityInhibitory gating

More Related Videos

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control
09:37

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Published on: July 5, 2015

9.2K
Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

10.1K

Related Experiment Videos

Last Updated: Oct 10, 2025

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.3K
Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control
09:37

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Published on: July 5, 2015

9.2K
Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

10.1K

Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Visual Perception

Background:

  • Selective attention is crucial for filtering sensory information and prioritizing relevant stimuli.
  • Top-down attention influences visual processing via alpha-rhythmic functional connections, but dynamic effects are unclear.

Purpose of the Study:

  • To investigate the local and network effects of selective attention on visual processing.
  • To understand the dynamic influence of top-down attention on downstream visual processing.

Main Methods:

  • Electroencephalography (EEG) was used to record brain activity.
  • Subjects attended to specific features of identical visual stimuli.
  • Functional brain network organization and connectivity were analyzed.

Main Results:

  • Attention-related changes in brain network organization occurred rapidly after stimulus onset.
  • Overall functional connectivity decreased during selective attention.
  • A sequential release from alpha-band parietal gating was observed in feature-selective areas.

Conclusions:

  • Selective attention dynamically reorganizes functional brain networks.
  • Alpha-band gating mechanisms facilitate prioritized processing of relevant visual features.
  • This provides a neural basis for rapid information prioritization in specialized visual areas.