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Bronchopulmonary Dysplasia and Risk of Developmental Delay: An EPIPAGE-2 Cohort Study

Ludovic Tréluyer1, Pierre-Henri Jarreau1,2, Laetitia Marchand-Martin1

  • 1Epidemiology and Statistics Research Center/CRESS, INSERM, INRAE, University of Paris, Paris, France.

Neonatology
|December 8, 2021
PubMed

Insights

Bronchopulmonary dysplasia (BPD) in preterm infants is linked to a higher risk of developmental delays. This study confirms the persistent association between BPD and neurodevelopmental outcomes in premature children.

Area of Science:

  • Neonatal Medicine
  • Pediatric Neurology
  • Developmental Pediatrics

Background:

  • Bronchopulmonary dysplasia (BPD) management and pathophysiology are evolving.
  • The neurodevelopmental consequences of BPD require ongoing investigation.

Discussion:

  • This study re-evaluates the association between BPD and developmental delay in a contemporary cohort.
  • Understanding persistent risks is crucial for early intervention strategies.

Key Insights:

  • Bronchopulmonary dysplasia (BPD) significantly increases the risk of developmental delay in preterm children.
  • The association was confirmed using the Age & Stages Questionnaires (ASQ) at 24 months corrected age.
  • An odds ratio of 1.52 (95% CI 1.11-2.08) highlights the strength of this association.

Outlook:

  • Further research should explore specific interventions to mitigate neurodevelopmental risks in infants with BPD.
  • Longitudinal studies are needed to track the long-term developmental trajectories of children with BPD.
Abstract

Keywords:
Bronchopulmonary dysplasiaDevelopmental delayVery preterm

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