Related Experiment Video
Updated: Oct 10, 2025

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
A Home-Based Individual Cognitive Stimulation Program for Older Adults With Cognitive Impairment: A Randomized
Rosa Silva1, Elzbieta Bobrowicz-Campos1,2, Paulo Santos-Costa1
1Health Sciences Research Unit: Nursing, Nursing School of Coimbra, Coimbra, Portugal.
Caregivers delivering a home-based cognitive stimulation program (iCS) showed promising results in improving cognitive function in persons with cognitive impairment (PwCIs). The intervention was feasible and meaningful for participants, offering a valid non-pharmacological approach.
Area of Science:
- Gerontology
- Neuroscience
- Cognitive Psychology
Background:
- Cognitive impairment significantly impacts individuals and their caregivers.
- Non-pharmacological interventions are crucial for managing cognitive decline and frailty.
- Home-based programs delivered by caregivers offer a scalable approach to support persons with cognitive impairment (PwCIs).
Purpose of the Study:
- To assess the feasibility and meaningfulness of a home-based individual cognitive stimulation (iCS) program delivered by caregivers to PwCIs.
- To evaluate the program's impact on cognitive, neuropsychiatric, and depressive symptoms, and quality of life in PwCIs.
- To examine the program's effects on caregivers' mental and physical health.
Main Methods:
- A randomized controlled trial (RCT) involving PwCI-caregiver dyads.
- Intervention group received the MD3-P iCS program (3x/week for 12 weeks); control group received usual care.
- Feasibility assessed via attrition, adherence, and satisfaction; outcomes measured at baseline and week 13.
Main Results:
- Attrition rate was 23.1%.
- Significant improvements observed in PwCIs' cognition, specifically orientation and ability to follow commands.
- No significant impact on caregivers' mental or physical health, or other PwCI outcomes.
Conclusions:
- Caregiver-delivered iCS (MD3-P) shows promise for improving cognitive function in PwCIs.
- The program is feasible and perceived as meaningful by participants.
- iCS represents a valid non-pharmacological strategy for reducing frailty in community-dwelling PwCIs.
Related Concept Videos
Cognitive Development During Adulthood
Alzheimer's Disease: Treatment

