Vascular cell-matrix adhesion in development and cancer
Christina Arapatzi1, Georgia Rouni1,2, Vassiliki Kostourou1
1Institute of BioInnovation, Biomedical Sciences Research Centre "Alexander Fleming", Vari-Athens, Greece.
The International Journal of Developmental Biology
|December 9, 2021
Summary
Cell-matrix adhesions are crucial for forming blood vessels in vertebrates. This review details their role in both normal development and tumor growth, highlighting endothelial cell functions.
Area of Science:
- Vascular biology
- Cell biology
- Developmental biology
Background:
- Vertebrate development relies on a complex vascular network.
- Cytokines, growth factors, and Notch signaling influence blood vessel formation.
- The precise molecular mechanisms of angiogenesis remain incompletely understood.
Purpose of the Study:
- To review the role of cell-matrix adhesions in endothelial cells.
- To summarize current knowledge on cell-matrix adhesion in developmental and tumor angiogenesis.
Main Methods:
- Literature review focusing on endothelial cell biology.
- Analysis of genetic studies and animal models.
Main Results:
- Cell-matrix adhesions are identified as key regulators of vascular morphogenesis.
- The review consolidates findings on the function of endothelial cell-matrix adhesions.
Conclusions:
- Cell-matrix adhesions are critical for blood vessel development and tumor angiogenesis.
- Further research into these adhesion mechanisms is warranted.
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