EANM procedure guidelines for brain PET imaging using [¹⁸F]FDG, version 3.

Area of Science:

• Nuclear medicine
• Neuroimaging
• Radiopharmaceuticals

Background:

• Previous guidelines for [18F]FDG-PET brain imaging were published in 2009.
• Advances in PET technology, including digital PET and hybrid PET/MR systems, necessitate updated recommendations.
• New clinical indications and a better understanding of hyperglycemia effects require revised protocols.

Purpose of the Study:

• To provide comprehensive procedural guidelines for [18F]FDG-PET brain imaging.
• To assist nuclear medicine practitioners in all aspects of brain PET procedures.
• To enhance the diagnostic utility of [18F]FDG-PET in neurological, neurosurgical, and psychiatric fields.

Main Methods:

• Summarization of current views from the EANM Neuro-Imaging Committee (NIC).
• Inclusion of updates on digital PET, hybrid PET/MR, and advanced semiquantitative analysis.
• Review of patient preparation, considering hyperglycemia effects.

Main Results:

• Updated recommendations for performing, interpreting, and reporting [18F]FDG-PET brain scans.
• Inclusion of typical metabolic patterns for neurodegenerative diseases.
• Guidance tailored for European practice, adaptable to local conditions.

Conclusions:

• These guidelines aim to standardize high-quality [18F]FDG-PET brain imaging.
• The updated procedures will improve diagnostic accuracy across various neurological and psychiatric conditions.
• The document serves as a crucial resource for nuclear medicine professionals.