Effect of Surface Layer Proteins Derived from Paraprobiotic Kefir Lactic Acid Bacteria on Inflammation and High-Fat Diet-Induced Obesity
Related Experiment Video
Updated: Jun 16, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Eseul Kim1, Hyeon Gyu Lee1, Sanghoon Han1
1Department of Food and Nutrition, Hanyang University, Seoul 04763, South Korea.
Abstract:
The antiobesity action of nonviable probiotic lactic acid bacteria (PLAB) may be attributed to bacterial cellular components recognized by host cells. The anti-inflammation and antiobesity properties of surface layer proteins (SLPs) that are cellular components isolated from kefir PLAB were determined in macrophage RAW 264.7 cells and obese mice. Kefir SLPs significantly decreased secretion of IL-6 and production of NF-kB p65 protein by LPS-stimulated RAW 264.7 cells in a dose-response manner. C57BL/6J mice were fed a high-fat (HF) diet with oral administration of either saline (CON) or kefir SLPs for 6 weeks. SLPs significantly improved body weight gain and adipose tissue weight, plasma triglyceride concentrations, and insulin resistance. Profiling of adipocyte gene expression showed that the antiobesity effect was significantly related to the expression of genes associated with adipogenesis, autophagy, and inflammatory/immune response, and fatty acid oxidation. Taken together, SLPs are a novel bioactive component in kefir PLABs to target obesity and obesity-related disorders.
More Related Videos
Related Concept Videos
Microbes in Food Production
Probiotics
Dysbiosis of the Gut Microbiota
Microbiota Modulation by Antibiotics
Gastritis II: Pathophysiology

