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The Association between Myopia and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis
Jian Wu1, Jie Hao1,2, Yifan Du1
1Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Capital Medical University, Beijing, China.
Ophthalmic Research
|December 9, 2021
Summary
Myopia is a risk factor for primary open-angle glaucoma (POAG) but may protect against its progression. Further research is needed to understand the underlying mechanisms of this complex relationship.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Myopia Studies
Background:
- The relationship between myopia and primary open-angle glaucoma (POAG) has been debated, with conflicting results from previous studies.
- Understanding this association is crucial for glaucoma diagnosis and management.
Approach:
- A systematic literature search was conducted across PubMed, Embase, and Scopus databases (1970-2020).
- Pooled analysis of odds ratios (ORs) was performed using random-effects models for cross-sectional and longitudinal studies.
Key Points:
- Myopia was associated with an increased risk of POAG (pooled OR = 2.26).
- Myopia showed a protective effect against POAG progression (pooled OR = 0.85).
- Heterogeneity was high in both analyses (I2 = 86% and 88%).
Conclusions:
- Myopia may be a risk factor for developing POAG.
- Myopia might act as a protective factor against the progression of POAG.
- Potential mechanisms, such as lamina cribrosa defects, warrant further investigation.
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