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Related Concept Videos

Histone Variants at the Centromere02:30

Histone Variants at the Centromere

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Oct 10, 2025

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Histone 3 Lysine 27 Trimethylation Signature in Breast Cancer.

Lidia Borkiewicz1

  • 1Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-059 Lublin, Poland.

International Journal of Molecular Sciences
|December 10, 2021
PubMed
Summary

Trimethylation of histone 3 lysine 27 (H3K27me3) is crucial in cancer. This review explores H3K27me3

Keywords:
chromatin modificationgene silencinghistone methylationhistone post-translational modificationstranscriptional regulation

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Biology

Background:

  • Cancer progression involves genetic and epigenetic alterations affecting gene expression.
  • Epigenetic mechanisms like DNA methylation and histone modifications regulate gene transcription.
  • Chromatin modification marks are implicated in normal development and cancer, including breast cancer.

Purpose of the Study:

  • To review the role of histone 3 trimethylation of lysine 27 (H3K27me3) in breast cancer.
  • To present evidence linking H3K27me3 status to breast cancer biology and patient outcomes across subtypes.
  • To discuss therapeutic strategies targeting H3K27me3 and its interactions with other epigenetic factors.

Main Methods:

  • Literature review of existing evidence on H3K27me3 in breast cancer.
  • Analysis of H3K27me3's role in gene silencing, particularly tumor suppressor genes.
  • Exploration of the cross-talk between H3K27me3, other chromatin modifications, and long non-coding RNAs (lncRNAs).

Main Results:

  • H3K27me3 is a significant epigenetic mark involved in silencing tumor suppressor genes.
  • The status of H3K27me3 is linked to breast cancer subtypes and patient prognosis.
  • H3K27me3 exhibits cross-talk with other epigenetic regulators and lncRNAs.

Conclusions:

  • H3K27me3 plays a critical role in breast cancer development and progression.
  • Targeting H3K27me3 represents a potential therapeutic avenue for breast cancer treatment.
  • Understanding H3K27me3's interactions is key to developing effective epigenetic therapies.