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Function of Centriolar Satellites and Regulation by Post-Translational Modifications
Clotilde C N Renaud1, Nicolas Bidère1
1CNRS, CRCINA, INSERM, Université de Nantes, Nantes, France.
Frontiers in Cell and Developmental Biology
|December 10, 2021
Summary
Centriolar satellites are dynamic granules crucial for centrosome function and primary cilia formation. New research reveals their complex roles in cellular processes like proteostasis and stress, influenced by post-translational modifications.
Area of Science:
- Cell Biology
- Molecular Biology
Background:
- Centriolar satellites are non-membrane granules associated with the centrosome.
- Initially linked to centrosome homeostasis and primary cilia assembly.
- Recent proteomic and interactomic studies reveal a complex composition of centriolar satellites.
Purpose of the Study:
- To review the main features and diverse roles of centriolar satellites.
- To discuss the impact of post-translational modifications on satellite composition and function.
Main Methods:
- Literature review of recent advances in centriolar satellite research.
- Analysis of proteomic and interactomic data.
- Discussion of post-translational modifications (phosphorylation, ubiquitination).
Main Results:
- Centriolar satellites are involved in more cellular processes than previously known, including proteostasis, autophagy, and cellular stress.
- Hundreds of new satellite components have been identified, highlighting their complexity.
- Post-translational modifications significantly influence satellite composition and function.
Conclusions:
- Centriolar satellites are complex, dynamic structures with multifaceted roles in cellular biology.
- Understanding the regulation of centriolar satellites by post-translational modifications offers potential therapeutic avenues.
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