Necrotizing sarcoid granulomatosis simulating pulmonary malignancy: A case report

Area of Science:

• Pulmonology
• Pathology

Background:

• Necrotizing sarcoid granulomatosis (NSG), now termed "sarcoidosis with NSG pattern," is a rare entity characterized by sarcoid-like granulomas, vasculitis, and necrosis.
• Its rarity and nonspecific symptoms pose diagnostic challenges, often leading to misdiagnosis or delayed diagnosis.

Observation:

• A 67-year-old female presented with a chest CT scan suggestive of pulmonary malignancy.
• Biopsy confirmed sarcoidosis with NSG pattern.

Findings:

• The patient underwent video-assisted thoracoscopic surgery for lung biopsy.
• No further treatment was administered post-biopsy.

Implications:

• Follow-up imaging revealed spontaneous regression of the disease within 2 months.
• Increased awareness of sarcoidosis with NSG pattern and its overlapping radiologic features with pulmonary malignancy is crucial for precise diagnosis and differential diagnosis.