Related Experiment Video
Updated: Oct 10, 2025

Author Spotlight: Simulation and Analysis of the Temperature Rise of Ring Main Unit Equipment
Published on: July 5, 2024
IFT trains overcome an NPHP module barrier at the transition zone
Kwangjin Park1,2, Michel R Leroux3,4
1Terry Fox Laboratory, BC Cancer, Vancouver, British Columbia, Canada.
Abstract:
Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transition zone (TZ) region and employ an intraflagellar transport (IFT) system to form dynamic motile and signaling compartments. In this issue, De-Castro and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010178) uncover a long-suspected role for the TZ in gating IFT particles.
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