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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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[Skeletal changes in plasma cell dyscrasias].

Tim Frederik Weber1, Theresa Mokry2,3

  • 1Sektion Radiologie in der Inneren Medizin, Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland. tim.weber@med-uni-heidelberg.de.

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|December 10, 2021
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Summary

Whole-body CT and MRI are crucial for diagnosing plasma cell dyscrasias, like multiple myeloma. Imaging aids in treatment stratification and monitoring disease progression, guiding patient management effectively.

Keywords:
Computed tomographyMagnetic resonance imagingMonoclonal gammopathyMultiple myelomaWhole-body imaging

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Area of Science:

  • Hematology
  • Radiology
  • Oncology

Background:

  • Plasma cell dyscrasias involve clonal plasma cell proliferation.
  • Key conditions include monoclonal gammopathy of unknown significance, smoldering multiple myeloma, and symptomatic multiple myeloma.

Purpose of the Study:

  • To review bone and bone marrow imaging findings of plasma cell dyscrasias using whole-body CT and MRI.
  • To discuss the clinical relevance of imaging in managing these conditions.

Main Methods:

  • Literature search of original research articles and reviews.
  • Analysis of dedicated studies and clinical guidelines.

Main Results:

  • Diagnostic classification relies on SLiM-CRAB criteria.
  • CT detects osteodestruction, while MRI identifies bone marrow infiltration.
  • Distinct patterns of bone marrow infiltration and signs of treatment response are observable.

Conclusions:

  • Imaging is vital for initial treatment stratification of plasma cell dyscrasias.
  • Radiological assessment is essential during patient follow-up.