Factors Threatening Central Visual Function of Patients with Advanced Glaucoma: A Prospective Longitudinal...

Area of Science:

• Ophthalmology
• Glaucoma Research
• Visual Function Studies

Background:

• Advanced glaucoma poses a significant risk for central vision deterioration.
• Intraocular pressure (IOP) control is crucial but may not prevent all vision loss.
• Identifying prognostic factors is essential for managing advanced glaucoma patients.

Purpose of the Study:

• To identify risk factors for the progression of central visual function in advanced glaucoma.
• To analyze the impact of baseline characteristics on visual field and acuity decline.
• To establish predictors for visual deterioration in a 5-year prospective study.

Main Methods:

• A 5-year prospective observational study involving 175 advanced glaucoma patients.
• Regular assessments included Humphrey Field Analyzer (HFA) 10-2 and 24-2 tests, and best-corrected visual acuity (BCVA).
• Cox proportional hazards models were used to determine risk factors for visual function deterioration.

Main Results:

• Lower baseline BCVA was linked to HFA 10-2 deterioration.
• Better HFA 24-2 mean deviation (MD) and systemic antihypertensive use predicted HFA 24-2 deterioration.
• Increased β-peripapillary atrophy, antihypertensive use, and lower BCVA predicted BCVA deterioration.

Conclusions:

• Baseline BCVA, β-peripapillary atrophy, and systemic antihypertensive use are significant prognostic factors in advanced glaucoma.
• These factors predict further deterioration of central visual function even with controlled IOP.
• Understanding these predictors can guide proactive management strategies for advanced glaucoma.