p62 works as a hub modulation in the ageing process.

Area of Science:

• Cellular Biology
• Molecular Biology
• Aging Research

Background:

• p62 (SQSTM1) is a key indicator of autophagic flux, essential for maintaining protein homeostasis.
• It functions as a stress-induced scaffold protein, crucial for resisting oxidative stress.
• p62 interacts with signaling pathways, autophagy, and the ubiquitin-proteasome system (UPS), impacting cell proliferation, apoptosis, and survival.

Purpose of the Study:

• To review and detail the mechanisms by which p62 regulates aging.
• To explore p62's role in various aging-related phenotypes.
• To provide novel insights into p62's function in the aging process.

Main Methods:

• Literature review of recent studies on p62 and aging.
• Analysis of p62's involvement in cellular stress responses.
• Examination of p62's interactions with key cellular pathways.

Main Results:

• p62 is implicated in multiple aging-related signs.
• Its regulatory functions extend to cellular survival and homeostasis.
• Evidence suggests a direct or indirect role of p62 in the aging process.

Conclusions:

• p62 plays a significant role in regulating aging.
• Understanding p62's function offers new avenues for aging research.
• Further investigation into p62 is warranted for its implications in age-related decline.