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Felicitas Bardehle1, Katharina Sies1, Alexander Enk1

  • 1Hautklinik, Universitätsklinikum Heidelberg.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|December 11, 2021
PubMed
Summary
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Psoriasis patients show significant nailfold capillary changes, including reduced density and increased abnormalities. These microvascular alterations correlate with higher inflammation and early atherosclerosis markers, suggesting a link to cardiovascular risk.

Area of Science:

  • Dermatology and Cardiovascular Medicine
  • Microcirculation Research
  • Vascular Biology

Context:

  • Psoriasis is an independent cardiovascular risk factor.
  • Microvascular changes in psoriatic plaques are known, but changes in unaffected skin are understudied.
  • Nailfold capillaries in unaffected skin of psoriasis patients offer a window into systemic microvascular health.

Purpose:

  • To systematically investigate nailfold capillary alterations in psoriasis patients using digital videocapillaroscopy.
  • To correlate these microvascular findings with patient characteristics, disease severity, inflammatory markers, and carotid artery intima-media thickness.
  • To explore the potential of nailfold capillaroscopy in assessing cardiovascular risk in psoriasis.

Summary:

  • Digital videocapillaroscopy revealed significant microvascular changes in the nailfold capillaries of psoriasis patients compared to controls.

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  • These changes included reduced capillary density, increased dilation, branching, tortuosity, and irregularities.
  • Psoriasis patients exhibited higher inflammatory serum markers and increased carotid artery intima-media thickness, correlating with the observed capillary abnormalities.

    • Impact:

    • Demonstrates distinct microvascular abnormalities in the nailfold capillaries of psoriasis patients, extending beyond affected skin areas.
    • Highlights a correlation between these nailfold capillary changes, systemic inflammation, and early signs of atherosclerosis.
    • Suggests that nailfold capillaroscopy may serve as a valuable tool for evaluating cardiovascular risk in individuals with psoriasis.