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A case of Podocytic Infolding Glomerulopathy with SLE and literature review

Xi Liu1, Jieli Huang1, Kun Zhang1

  • 1The Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

BMC Nephrology
|December 13, 2021
PubMed
Abstract

Insights

Podocytic infolding glomerulopathy (PIG), a rare kidney disease characterized by microspheres in the glomerular basement membrane, is presented in a patient with systemic lupus erythematosus.

Area of Science:

  • Nephrology
  • Pathology
  • Immunology

Background:

  • Podocytic infolding glomerulopathy (PIG) is a rare kidney disease characterized by unique microsphere or microtubular structures within the glomerular basement membrane (GBM).
  • Few cases of PIG have been documented globally, highlighting its rarity.

Observation:

  • A 61-year-old female with systemic lupus erythematosus presented with proteinuria, effusions, cytopenias, and positive autoimmune markers.
  • Renal biopsy revealed granular IgM and C3 deposition, atypical for lupus nephritis.
  • Electron microscopy identified numerous microsphere structures within a thickened GBM.

Findings:

  • The case highlights a rare instance of podocytic infolding glomerulopathy (PIG) co-occurring with systemic lupus erythematosus (SLE).
  • Distinctive microsphere structures within the GBM were observed, characteristic of PIG.
  • Immunofluorescence showed non-specific granular deposition of IgM and C3, differing from typical lupus nephritis patterns.

Implications:

  • This case expands the understanding of PIG's clinical spectrum, suggesting an association with connective tissue diseases like SLE.
  • Further research into the pathogenesis of PIG is warranted, potentially involving podocyte injury mechanisms.
  • The findings underscore the importance of comprehensive renal pathology evaluation in patients with SLE presenting with atypical renal manifestations.
Keywords:
EB virusOvarian tumorPodocytes,Systemic lupus erythematosusPodocytic infolding glomerulopathy

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