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The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
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Toxocariasis affecting brain stem and skull base.

Manuel Gomez Serrano1, Rafael Jimenez Rodriguez-Madridejos2, Salome Merino Menendez3

  • 1ENT Department, Hospital Clínico San Carlos, Universidad Complutense, Calle Profesor Martin Lagos s/n. 5ª Planta, Madrid, Spain. manuelgts@hotmail.com.

BMC Infectious Diseases
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Summary
This summary is machine-generated.

Toxocariasis, a parasitic infection, can manifest as skull base lesions. Early diagnosis and albendazole treatment are crucial for controlling this rare but treatable condition.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Parasitology

Background:

  • Toxocariasis is a neglected tropical disease caused by *Toxocara* nematodes.
  • Humans act as paratenic hosts, with disease arising from parasite migration.
  • Otorhinolaryngological manifestations are uncommon but possible.

Observation:

  • A 60-year-old male presented with headache, otorrhea, and ear pain.
  • Imaging revealed a nasopharyngeal mass with skull base infiltration, intracranial extension, and a pontine lesion.
  • Biopsies were negative for malignancy, but positive serology for *Toxocara canis* (IgG ELISA) and clinical suspicion led to a diagnosis of toxocariasis.

Findings:

  • The patient received albendazole and corticosteroids, leading to disease control.
  • Follow-up imaging after one year showed significant lesion reduction in the clivus and pons.
  • Negative post-treatment serology confirmed treatment efficacy.

Implications:

  • *Toxocara canis* infection should be considered in the differential diagnosis of skull base lesions, especially with negative tumor histology.
  • Albendazole is an effective treatment for controlling and curing toxocariasis.
  • This case highlights the importance of considering parasitic infections in complex neurological presentations.