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The centriolar tubulin code.

Paul Guichard1, Marine H Laporte1, Virginie Hamel1

  • 1University of Geneva, Department of Cell Biology, Geneva, Switzerland.

Seminars in Cell & Developmental Biology
|December 13, 2021
PubMed
Summary
This summary is machine-generated.

Centrioles, essential for cell division and cilia, feature tubulin with post-translational modifications (PTMs). This review explores how these PTMs influence centriole architecture and function.

Keywords:
Basal bodiesCentriolesCryo-EMExpansion microscopyPTMsTubulin

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Structural Biology

Background:

  • Centrioles are vital microtubule-based organelles in eukaryotic cells.
  • They are crucial for cell division (as part of the centrosome) and cilia formation.
  • Centriolar tubulin undergoes post-translational modifications (PTMs) like glutamylation and acetylation.

Purpose of the Study:

  • To review current knowledge on PTMs in centrioles.
  • To explore the potential link between PTMs and centriole architecture.
  • To propose hypotheses regarding the function of tubulin PTMs in centrioles.

Main Methods:

  • Literature review of existing studies on centriolar PTMs.
  • Analysis of data linking PTMs to centriole structure and stability.
  • Synthesis of findings to propose functional roles for PTMs.

Main Results:

  • PTMs on centriolar tubulin are widespread.
  • Evidence suggests PTMs may play a role in centriole stability.
  • The precise functions of PTMs in centriole architecture remain largely unknown.

Conclusions:

  • PTMs are key modifications of centriolar tubulin.
  • Further research is needed to elucidate the functional significance of PTMs in centriole assembly, architecture, and function.
  • Understanding PTMs could reveal new insights into cell division and cilia biology.