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Updated: Oct 10, 2025

Modeling the Functional Network for Spatial Navigation in the Human Brain
Published on: October 13, 2023
Early and late development of hub connectivity in the human brain
Stuart Oldham1, Gareth Ball2, Alex Fornito3
1The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University, Victoria, Australia; Developmental Imaging, Murdoch Children's Research Institute, Victoria, Australia.
Abstract:
Human brain networks undergo pronounced changes during development. The emergence of highly connected hub regions that can support integrated brain function is central to this maturational process, with these areas undergoing a particularly protracted period of development that extends into adulthood. The location of cortical network hubs emerges early but connections to and from hubs continue to strengthen throughout childhood and adolescence. Patterns of functional coupling in cortical association hubs are immature and incomplete at birth, but gradually strengthen during development. Early establishment of hub connectivity may provide a stable substrate that is refined by changes in tissue organization and microstructure, resulting in the emergence of complex functional dynamics by adulthood.
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